Beckman.com is conducting maintenance Saturday, September 19th and Sunday, September 20th. Parts of the site may have limited accessibility throughout the weekend. During this time, orders can still be placed by calling Client Services. We look forward to providing an improved customer experience. Beckman.com will return Monday, September 21st.
To create CAR-T cells, the genetic material coding the engineered receptor must be delivered to and incorporated within the host T cell genome. Delivery can be accomplished through a variety of methods, including plasmid transfection and viral vector transduction, but stable gene transfer and transcription is required for sustained CAR surface expression. Stably transfected/transduced CAR-T cells can then be selected, expanded, and used for research or therapeutic purposes.1
1. X. Wang and I. Rivière, “Clinical manufacturing of CAR T cells: foundation of a promising therapy,” Mol Ther Oncolytics 3:16015, 2016.
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